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LTRN has cash, cash equivalents, and marketable securities of roughly $38.4 million as of March 31, 2024

RADR® is among the world’s largest, most comprehensive and fastest growing AI-based oncology drug discovery and development platforms, with over 25 billion data points and 200+ algorithms powering a wide range of cancer drug development issues

Starlight Therapeutics, a wholly owned subsidiary of Lantern Pharma focused on CNS and brain cancers with STAR-001, advanced with the filing of a clinical trial protocol for the Phase 1B dose optimization and expansion cohort in recurrent IDH wild-type high grade gliomas

READ THE INVESTOR PRESENTATION HERE

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**BREAKING NEWS RELEASED THIS MORNING*****

Lantern Pharma Announces Positive Clinical Update from Ongoing Phase 2 HARMONIC™ Clinical Trial for Never Smokers with Advanced NSCLC, Including an 86% Clinical Benefit Rate in the Initial Patient Cohort

PUBLISHED

AUG 5, 2024 8:00AM EDT

• The Phase 2 HARMONIC™ study is designed for never smokers with lung adenocarcinoma with the objective to overcome driver mutation(s) – which are more common in never smokers – that lead to tyrosine kinase inhibitor (TKI) treatment resistance, and to enhance patient outcomes when LP-300 is used with the standard-of-care chemotherapy doublet.
• In the Phase 2 lead-in cohort of 7 patients, 6 patients experienced clinical benefit from the combination of LP-300 and chemotherapy while 1 patient experienced progressive disease.
• Of the 6 patients experiencing clinical benefit – 3 patients showed partial responses with an average tumor size reduction of 51% and 3 patients have stable disease with an average tumor size reduction of 13%.
• The clinical benefit rate and disease control rate is 86% for this group with an objective response rate (ORR) of 43%.
• A preliminary analysis of data in the safety lead-in part of the trial indicates no additional safety concerns with no observed dose limiting toxicities (DLTs) and no reported treatment-related serious adverse events (SAEs).
• Encouraging preliminary efficacy results were observed regardless of prior tyrosine kinase inhibitor (TKI) treatment(s), demographics, and metastatic disease sites.
• In the initial set of patients, those having low to intermediate TMB (tumor mutation burden) were found to be responsive to LP-300 + chemotherapy.
• There are no currently approved therapies or targeted agents specifically approved for use in NSCLC among never-smokers, which is a growing global class of patients.

DALLAS--(BUSINESS WIRE)-- Lantern Pharma (NASDAQ: LTRN), an artificial intelligence (AI) company dedicated to developing cancer therapies and transforming the cost, pace, and timeline of oncology drug discovery and development, today announced positive, preliminary results from the initial patient group in the ongoing HARMONIC™ phase 2 clinical trial. HARMONIC™ is evaluating Lantern Pharma’s investigational new drug candidate, LP-300, in combination with pemetrexed and carboplatin in never smokers1 with advanced non-small cell lung cancer (NSCLC) who have progressed after receiving treatment with a tyrosine kinase inhibitor (TKI). LP-300 was advanced in part with Lantern’s AI platform, RADR®, to aid in the validation of mechanisms and uncover insights in targeted patient populations. RADR® is Lantern’s AI platform for cancer therapy discovery, development and rescue with over 100 billion data points and aiding in the development of both Lantern’s portfolio and development initiatives with Lantern’s collaborators.This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240805396240/en/

Harmonic® Clinical Trial - Percent change in cancer lesion size by patient (Graphic: Business Wire)Summary of Harmonic™ Clinical ResultsFor the initial safety lead-in portion of the Phase 2 study, which involved 7 patients, all patients received the LP-300 drug candidate with pemetrexed and carboplatin intravenously2. Preliminary results at the completion of the 7-patient lead-in part of the Harmonic™ study demonstrated predictable safety profiles that are consistent with the chemotherapy regimen alone. No patients experienced dose limiting toxicities, and no discontinuations were observed due to treatment related toxicity. The most common adverse events were white blood cell count decrease and thrombocytopenia (platelet count decrease).Of the 7 patients enrolled in the Phase 2 lead-in stage of the Harmonic™ trial:

1. The clinical benefit rate (CBR) or disease control rate (DCR) was 86% with 6 of the 7 patients receiving clinical benefit to date.
2. The preliminary objective response rate (ORR) was 43%, with 3 of the 7 patients having a partial response and 3 patients having stable disease.
3. The 3 partial responses include complete disappearance of metastatic lesions and/or normalization of lymph nodes that were abnormal at baseline and the patients experienced an average of 51% reduction in tumor sizes as measured by RECIST criteria.
4. In the 3 patients achieving stable disease, there was an average of 13% reduction in tumor size with two patients having distal lesions reduced by 40% in tumor size.
5. One patient has been on study for 14 months, showing both a 57% reduction in tumor size and a significant durability of response.
6. Data for the remainder (5 of 6) of these patients is not yet mature for estimation of median duration of response and progression free survival (PFS) at the time of data cut off (07/25/24).
7. Preliminary efficacy results were observed regardless of prior TKI treatment(s), demographics, or metastatic disease sites, including in patients with identified low or intermediate tumor mutational burden (TMB); a patient group that is particularly unresponsive to existing immuno-oncology therapies.

"These initial results from the Harmonic™ trial provide preliminary clinical evidence of both the safety and the mode of action for LP-300 in never-smokers with NSCLC. To see such a high clinical benefit rate, which is part of our secondary endpoints, this early in the trial is a motivating factor for accelerating our enrollment globally," said Lantern VP of Clinical Development Reggie Ewesuedo, MD, MBA.The randomization and expansion phase of the Harmonic™ study is currently ongoing and will assess the Progression Free and Overall Survival (PFS and OS) when patients are treated with pemetrexed and carboplatin (with or without LP-300). The full study design can be viewed here (clinicaltrials.gov).Other Harmonic Clinical Trial Observations & UpdatesNever smokers with NSCLC who progress on treatment with available TKIs are often not candidates for treatment with checkpoint modulator immunotherapy. These patients can often be faced with poor treatment outcomes when receiving the pemetrexed and carboplatin chemotherapy regimen alone, which is the current standard of care for this patient population when failing TKI therapies. This points to a significant clinical need for innovative and new options, especially those that present no overlapping or added toxicities with the standard-of-care chemo doublet.“Preliminary results indicate that this LP-300 triplet regimen is active against advanced NSCLC with actionable alterations and there were no unexpected adverse events. Also, the early Harmonic patient data indicates that the adverse events appear to be primarily due to chemotherapy and not the study drug,” said Janakiraman Subramanian, MD and Director of Thoracic Oncology at Inova Schar Cancer Institute.The proportion of never-smoking patients with non-small cell lung cancer (NSCLC) has been significantly increasing globally over the past 30 years, from 15% in the 1970s to 33% in the 2000s. The high proportion of never smokers with NSCLC in East Asian countries is of particular note with Japan estimated to be 33 to 40% of new cases and Taiwan at over 50% of new cases.3 Lantern has received regulatory approval to initiate the LP-300 clinical trial in multiple Asian countries, and has started activation of sites in Japan and Taiwan, including the National Cancer Center in Tokyo, a globally recognized center of cancer research excellence.Future Milestones & ActivityLantern Pharma is committed to further advancing the triplet combination regimen (LP-300 + pemetrexed +carboplatin) to potentially enhance patient outcomes, with the goal of extending and improving the lives of never smokers with advanced NSCLC adenocarcinoma. While this data is promising, Lantern will continue collecting and analyzing additional patient response and clinical data from sites in the US and Asia. If the additional data confirms our preliminary findings for clinical benefit and/or objective response rates, Lantern will consider applying for a Breakthrough Therapy designation. According to the FDA, Breakthrough Therapy designation is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint(s). No therapy has been specifically approved for never-smokers with NSCLC making this a significant and growing global clinical need, estimated by Lantern to be over $2 billion USDin annual market potential.The Harmonic™ study has progressed to the randomization and expansion phase where up to an additional 80 patients will be placed into either the LP-300 + standard-of-care chemotherapy doublet arm or the standard-of-care chemotherapy doublet arm without LP-300. The arm with LP-300 will enroll patients on a 2 to 1 ratio versus the arm with doublet chemotherapy alone. The study is designed to progress based on the 2 to 1 randomization in all sites across the US and Asia. Lantern plans to review, and share the interim data from, the Phase 2 trial for PFS and OS (co-primary endpoints) after 30 clinical events have been observed.Lantern also anticipates further using RADR® to determine potential additional suitability for LP-300 in combination with other approved agents for the control of cancer progression in other patient subgroups. Lantern has developed and published on LP-300 as a potential first-in-class combination agent with tyrosine kinase inhibitors (TKIs) in non-smoker lung adenocarcinoma which could extend the potential of the drug-candidate into earlier segments of NSCLC care. On Thursday, August 8th Lantern’s management will provide additional details on the positive Phase 2 trial results as well as clinical and scientific insight from the Harmonic™ study during the Company’s 2nd quarter earnings call at 4:30pm Eastern which can be accessed via Zoom webinar registration.About The HARMONIC™ Clinical TrialThe HARMONIC™ trial is designed as a multicenter, open label, multi-country Phase 2 trial with planned enrollment of approximately 90 patients. Patients who are never smokers with NSCLC adenocarcinoma and have relapsed after prior treatment with tyrosine kinase inhibitors will be eligible for enrollment. Following the safety lead-in stage, the trial will consist of randomization in a 2:1 allocation ratio of patients to one of two arms: Arm A (LP-300 + carboplatin, + pemetrexed) or Arm B (carboplatin + pemetrexed).About LP-300LP-300 is a disulfide small molecule and an investigational new drug candidate. It has been well characterized to have a multimodal mechanism of action directed towards tyrosine kinase receptors and cell redox enzymes. It is believed to modulate cellular redox in key signaling pathways in NSCLC and directly engage with TKI receptors via cysteine modification.It is known that lung carcinomas in never smoker patients have a much higher percentage of mutations in certain tyrosine kinase (TK) oncogenes such as EGFR, ALK, ROS, and MET-1, contributing to tumor formation and growth, while lung carcinomas in smokers are much more likely to have growth-driver mutations in oncogenes such as RAS, and much lower percentages of mutations in TK oncogenes. Both published (Parker 2015) and unpublished studies have shown that LP-300 covalently binds to and/or inhibits the kinase activity of each of these TK oncogenes (EGFR, ALK, ROS, and MET-1), suggesting that a greater number of lung adenocarcinomas in never smokers, compared to smokers, could be susceptible to the inhibitory effects of LP-300.LP-300 has been evaluated in 5 Phase 1 and 5 Phase 2 or 3 clinical trials in over 1,000 subjects. In a retrospective subgroup analysis from a prior Phase 3 trial, never smoker lung adenocarcinoma patients receiving the combination of LP-300 with cisplatin and paclitaxel chemotherapy were observed to have significant survival benefit compared to the never smoker patients receiving cisplatin and paclitaxel without LP-300.About Lantern Pharma:Lantern Pharma (NASDAQ: LTRN) is an AI company transforming the cost, pace, and timeline of oncology drug discovery and development. Our proprietary AI and machine learning (ML) platform, RADR®, leverages over 100 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, we have accelerated the development of our growing pipeline of therapies that span multiple cancer indications, including both solid tumors and blood cancers and an antibody-drug conjugate (ADC) program. On average, our newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0 - 2.5 million per program.Our lead development programs include a Phase 2 clinical program and multiple Phase 1 clinical trials. We have also established a wholly-owned subsidiary, Starlight Therapeutics, to focus exclusively on the clinical execution of our promising therapies for CNS and brain cancers, many of which have no effective treatment options. Our AI-driven pipeline of innovative product candidates is estimated to have a combined annual market potential of over $15 billion USD and have the potential to provide life-changing therapies to hundreds of thousands of cancer patients across the world.Please find more information at:

• Website: www.lanternpharma.com
• LinkedIn: https://www.linkedin.com/company/lanternpharma/
• X: @lanternpharma

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Hello Everyone,

We are back with another biotech for you to research this week.

This one has a catalyst this week that is noteworthy.

The company announced that it will host its second quarter 2024 operating and financial results on Thursday, August 8, 4:30 p.m. EST after the close.

Pull up LTRN right away.

This is another fresh company that is brand new to us here.

You are going to find some impressive technology while you are researching this one.

Lantern Pharma is an AI company transforming the cost, pace, and timeline of oncology drug discovery and development. Their proprietary AI and machine learning (ML) platform, RADR®, leverages over 25 billion oncology-focused data points and a library of 200+ advanced ML algorithms to help solve billion-dollar, real-world problems in oncology drug development. By harnessing the power of AI and with input from world-class scientific advisors and collaborators, they have accelerated the development of their growing pipeline of therapies including eleven cancer indications and an antibody-drug conjugate (ADC) program. On average, their newly developed drug programs have been advanced from initial AI insights to first-in-human clinical trials in 2-3 years and at approximately $1.0-2.0 million per program.

Their lead development programs include two Phase 2 clinical programs. They have also established a wholly-owned subsidiary, Starlight Therapeutics Inc., to focus exclusively on the clinical execution of their promising therapies for CNS and brain cancers, many of which have no effective treatment options. Their AI-driven pipeline of innovative product candidates are estimated to have a combined annual market potential of over $15 billion USD and have the potential to provide life-changing therapies to hundreds of thousands of cancer patients across the world.

LTRN is revolutionizing the fields of oncology drug discovery and development through its proprietary AI and machine learning platform, RADR®. Utilizing an extensive dataset of over 25 billion oncology-centric data points and a library of more than 200 advanced machine learning algorithms, the company addresses multi-billion-dollar challenges in the oncology drug development landscape. With guidance from an elite team of scientific advisors and collaborators, Lantern Pharma has expedited its growing portfolio of treatments. This includes eleven distinct cancer indications as well as an antibody-drug conjugate program. Remarkably, new drug programs propelled by Lantern Pharma's technology advance from initial AI-derived insights to first-in-human clinical trials within a 2-3 year time frame and at a cost of approximately $1.0-2.0 million per program. The company's AI-empowered pipeline has an estimated combined annual market potential exceeding $15 billion USD and holds the promise of delivering transformative therapies to hundreds of thousands of cancer patients.

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If you back to February and March of this year you will notice that this one took off from 4 Bucks and ran all the way to 12 on above average interest. The float on this one is fairly small at roughly 8 Million. This could be a major factor a to why LTRN was able to take off without notice.

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RECENT HIGHLIGHTS

Lantern Pharma Achieves Key Milestone Towards Development of Molecular Diagnostic for use in Oncology Clinical Trials for Patient Selection and Stratification with Drug Candidate LP-184

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DALLAS--(BUSINESS WIRE)-- Lantern Pharma (NASDAQ: LTRN), a clinical-stage biopharmaceutical company leveraging artificial intelligence (AI) and machine learning to transform the cost, pace, and timeline of oncology drug discovery and development, today announced a significant advancement towards the development of a diagnostic for its drug candidate LP-184. The diagnostic is currently based on qRT-PCR (quantitative real-time polymerase chain reaction) technology and is focused on quantifying the amount of PTGR1 RNA in patient tumor samples to assess the potential for sensitivity to Lantern’s drug candidate LP-184. The company plans to further develop and validate the assay for its use as a potential tool for patient selection in later stage clinical trials across a broad range of solid tumors that have shown sensitivity to LP-184.

Figure 1: Correlation of PTGR1 expression and cytotoxicity/potency (IC50, µM) of LP-184 (Graphic: Business Wire)

Lantern has successfully confirmed PTGR1 as a key biomarker that it intends to use to optimize patient selection based on potential tumor sensitivity to the drug candidate LP-184. LP-184 is a precision oncology drug candidate with the potential to address multiple solid tumors. This confirmation marks a crucial step towards the development of a companion diagnostic and potential stratification tool to assist with targeted patient selection. Lantern plans on further validations and development of the assay using qRT-PCR and partnering with central labs and cancer centers for eventual use in patient selection and stratification. In a key publication on the utility and value of biomarkers in oncology trials among some of the most common cancers, titled Does biomarker use in oncology improve clinical trial failure risk? A large‐scale analysis by Parker, et al., 2021 in Cancer Medicine found success of clinical trials to be significantly correlated to the incorporation of biomarkers. In particular, the Parker, et al. publication stated that:

“…Our overall analysis of these four cancers, independent of indication, revealed a fivefold benefit of hazard ratios from the Markov models, suggesting a substantial benefit from biomarker use. The hazard ratio analysis of the Markov biomarker models examined how likely clinical trial success was associated with biomarker use versus no biomarker use. Hazard ratios indicated that for biomarker‐based drugs clinical trial success was largest for breast cancer (12‐fold) followed by melanoma (eightfold) and lung cancer (sevenfold) …Our data provide the most extensive look at biomarker use to date in oncology, with an advanced statistical method. Our findings indicate that biomarkers provide a statistically significant benefit, despite the fact our study includes biomarkers not yet FDA approved.”

By incorporating the PTGR1 biomarker into LP-184's development strategy, Lantern Pharma is aligning with best practices in precision medicine and aiming to increase the likelihood of successful clinical outcomes in future clinical trials. PTGR1 levels have been measured to be higher in certain cancer cells than in normal cells, and Lantern is leveraging this biological activity to target the cancer indications believed most likely to respond to drug candidate LP-184. In the October 2023paper in Molecular Cancer Therapeutics, Lantern along with collaborators from Fox Chase Cancer Center published clear evidence that higher potency of LP-184 (measured in IC50 values) was directly correlated with higher expressions of PTGR1 and that cancer cell lines that did not have PTGR1 expression remained stable in the presence of LP-184 (see figure 1).

"This milestone represents a significant leap forward in our precision oncology approach and in ensuring that we enrich our future LP-184 clinical trials with the patients we believe will be most likely to benefit," said Panna Sharma, CEO of Lantern Pharma. "By working to develop a companion diagnostic for LP-184, we're not just advancing a drug candidate; we're paving the way for more personalized and effective cancer treatments for patients that have the highest likelihood of benefitting from the therapy. The planned use of biomarkers like PTGR1 in our clinical trials exemplifies our commitment to data-driven, patient-centric drug development."

These steps toward development of this companion diagnostic align with Lantern Pharma's commitment to leveraging cutting-edge technology in drug development. By combining AI-driven insights with advanced diagnostic tools, the company aims to accelerate the drug development process and improve patient outcomes.

Lantern Pharma plans to implement this assay in upcoming clinical trials for LP-184, potentially streamlining the development process and increasing the likelihood of successful outcomes. LP-184— a novel therapeutic in clinical development for the potential treatment of malignant gliomas, pancreatic cancer, and atypical teratoid rhabdoid tumors (ATRT)— has also been granted an Orphan Drug Designation by the FDA, along with a Rare Pediatric Disease Designation.

NEWS

• Lantern Pharma to Report Second Quarter 2024 Operating & Financial Results on August 8th, 2024 at 4:30 p.m. ET
• 1 day ago
• Lantern Pharma Achieves Key Milestone Towards Development of Molecular Diagnostic for use in Oncology Clinical Trials for Patient Selection and Stratification with Drug Candidate LP-184
• Jul 10, 2024
• Lantern Pharma Receives Certificate of Patent from Japanese Patent Office (JPO) for Composition of Matter Covering Drug Candidate LP-284
• Jun 12, 2024
• Lantern Pharma Reports First Quarter 2024 Financial Results and Business Highlights
• May 9, 2024
• Oregon Therapeutics & Lantern Pharma Launch Strategic AI Collaboration to Optimize Development of First-In-Class Drug Candidate XCE853 – A Potent Inhibitor of Cancer Metabolism
• May 6, 2024
• Lantern Pharma to Report First Quarter 2024 Operating & Financial Results on May 9th, 2024 at 4:30 p.m. ET
• May 2, 2024
• Lantern Pharma Launches “Webinar Wednesdays” Featuring World-Class Physician Scientists & Key Opinion Leaders Discussing Critical Areas of Oncology Drug Development
• Apr 24, 2024
• Lantern Pharma Receives Regulatory Approval to Expand Harmonic™ Clinical Trial for Non-Small Cell Lung Cancer in Never-Smokers into Japan and Taiwan
• Apr 22, 2024
• Lantern Pharma Reports Fourth Quarter & Fiscal Year 2023 Financial Results and Business Highlights
• Mar 18, 2024
• Lantern Pharma Announces Initial Patients Dosed in First-In-Human Clinical Trial for AI-Guided Drug-Candidate, LP-284
• Mar 15, 2024
• Lantern Pharma Reports Fourth Quarter & Fiscal Year 2023 Financial Results and Business Highlights
• Mar 18, 2024
• Lantern Pharma Announces Initial Patients Dosed in First-In-Human Clinical Trial for AI-Guided Drug-Candidate, LP-284
• Mar 15, 2024
• Lantern Pharma to Report Fourth Quarter and Fiscal Year 2023 Operating & Financial Results on March 18th, 2024 at 4:30 p.m. ET
• Mar 11, 2024
• Lantern To Participate in H.C Wainwright & Co.’s (HCW) 1st Annual Artificial Intelligence Based Drug Discovery & Development Virtual Conference
• Mar 5, 2024

MANAGEMENT TEAM

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Chief Executive Officer, President and Director

Panna Sharma

Passionate about the use of A.I. and machine learning to change the risk, cost, and timelines in the highly interdisciplinary field of personalized medicine.

Passionate about the use of A.I. and machine learning to change the risk, cost, and timelines in the highly interdisciplinary field of personalized medicine.
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Panna Sharma is the President, CEO, and Board Member of Lantern Pharma Inc., a clinical-stage oncology biotech using artificial intelligence (AI) and genomics to innovate the rescue, revitalization, and development of precision cancer therapeutics. Lantern is focused on improving patient outcomes by using its proprietary AI platform – Response Algorithm for Drug Repositioning & Rescue (RADR®) – to rescue, revitalize and develop abandoned or failed cancer drugs, and to accelerate their development through precision trials that help identify patient groups more likely to respond to its pipeline of targeted cancer therapies.
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As Chief Executive Officer, Panna is responsible for developing Lantern’s strategic vision, and working closely with the venture investors to raise capital that will place the Company at the forefront of using AI and genomics in developing its pipeline of precision therapies. The Lantern Pharma (LP) pipeline currently consists of four drug candidates and an ADC program across 8 tumor targets, including two phase 2 programs, all focusing on cancers that have unique and unmet clinical needs with a clearly defined patient population. These drugs can be targeted to patients whose profile identifies them as having the highest probability of benefiting from the drug, thereby achieving better outcomes with reduced costs and accelerated timelines.
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Prior to joining Lantern in 2018, Panna was the President and Chief Executive Officer of Cancer Genetics, Inc. (Nasdaq: CGIX), a provider of genomic and immune-based cancer diagnostics and therapy development services to some of the most prestigious medical institutions and pharma companies in the world. In his capacity as CEO at CGIX, he raised over $100 million in the public and private markets and grew the company from 25 employees in New Jersey to over 250 employees globally across multiple continents. Panna took CGIX public in 2013 and acquired four companies globally that help CGIX deliver on its mission to help personalize cancer treatment. Prior to CGIX, Panna founded TSG Partners, a specialty advisory group combining corporate strategy and corporate finance to create shareholder value for companies and investors in the life sciences, biotechnology, and environmental sciences. Panna began his career as an industry analyst for financial services and technology companies and was part of the management team that took the digital strategy and e-business company iXL public.
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Panna attended Boston University in the University Professors Program and focused his studies on Philosophy of Science, Neural Networks and Artificial Intelligence. When not focused on the future of biotech, machine learning, emerging technologies, and genomics, Panna can be found with his three children and wife and listening to music, attending sports functions, discussing new and ethical uses of A.I., debating language theories and enjoying the vibrant and evolving local food scene.
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Chief Financial Officer and Secretary

David R. Margrave

Mr. Margrave has served as our Chief Financial Officer since November 2019 and as our Secretary since June 2018. Since January 2016, Mr. Margrave has served as a life science consultant, providing strategic advisory and legal services to growing life science companies.

Mr. Margrave has served as our Chief Financial Officer since November 2019 and as our Secretary since June 2018.  Since January 2016, Mr. Margrave has served as a life science consultant, providing strategic advisory and legal services to growing life science companies.  From January 1995 to December 2015, he served as an executive officer at BioNumerik Pharmaceuticals, Inc., a life science company focused on advancing innovative cancer therapies.  During his time at BioNumerik Pharmaceuticals, Inc., Mr. Margrave served in various positions including service as President and as Chief Administrative Officer and General Counsel.  Mr. Margrave has served as a consultant to BioNumerik Pharmaceuticals, Inc. since January 2016.  From April 2015 to December 2016, he also served as Senior Legal Advisor to MedCare Investment Corporation, a private investment firm investing in the medical and healthcare services industries.  Prior to joining BioNumerik Pharmaceuticals, Inc., Mr. Margrave was a partner at Andrews & Kurth LLP, a national law firm.  Mr. Margrave serves as Chairman and a board member of the Texas Healthcare and Bioscience Institute and as Chairman and a board member of the State of Texas Product Development & Small Business Incubator Board.  He is a past board member of the Texas Technology Transfer Association.  Mr. Margrave received a Bachelor of Arts and Science degree in Economics and in Petroleum Engineering from Stanford University, and a J.D. degree from The University of Texas School of Law.

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Chief Scientific Officer

Kishor G. Bhatia, PhD

Dr. Bhatia has served as our Chief Scientific Officer since December 2019, and as our scientific consultant since January 2019. Dr. Bhatia also serves as a scientific consultant to Reprocell, one of our collaborators, since December 2016, and served as a scientific consultant to Cancer Genetics, Inc. from December 2016 until November 2019.

Dr. Bhatia has served as our Chief Scientific Officer since December 2019, and as our scientific consultant since January 2019.  Dr. Bhatia also serves as a scientific consultant to Reprocell, one of our collaborators, since December 2016, and served as a scientific consultant to Cancer Genetics, Inc. from December 2016 until November 2019.  Since 2006, he has been employed as an Adjunct Investigator with the National Cancer Institute-Division of Cancer Epidemiology and Genetics.  From January 2007 until July 2016, Dr. Bhatia also served as a Director-AIDS Malignancy Program at the National Cancer Institute-Office of HIV and AIDS Malignancy, and from January 2004 through January 2007, he served as a Program Director and the Director of the National Cancer Institute-Division of Cancer Treatment and Diagnosis.  Dr. Bhatia received a Bachelor of Science degree in microbiology from the University of Pune and a Ph.D. in biochemistry from the University of Mumbai. He is a Fellow of the Royal College of Pathology in the United Kingdom, was a Post-Doctoral Fellow at Johns Hopkins University and was a Research Assistant Professor at Georgetown University from 1985 to 1989.

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Sincerely,

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